Past Effectiveness Reviews | |||||
A research seminar for:
The University of Sheffield Psychology
Senior Clinical Psychologist
Neuropsychology
North Staffordshire Combined Healthcare NHS Trust
Overview of Practice Based Evidence.
Rationale for the Current Study.
Findings & Limitations.
Recent Developments.
Psychotherapy works! ✅.
Different therapies fare about equal (i.e., Dodo Bird Effect 🐦).
Some therapists produce greater outcomes (Super Shrinks? 🦸).
Providing feedback on progress leads to greater outcomes 🆙🍄.
Much improvement is actually achieved in the early sessions.
Advantages of RCTs
✅ Reduction of bias
✅ High internal validity
✅ Reproducibility
✅ Objective and reliable
However:
Many reasons to expect that that the effects of psychotherapy delivered in routine care settings may differ from RCTS:
Geographical effects.
Provision.
Empirically Supported Treatments.
Integrity.
So what do we do… ?
Past Effectiveness Reviews | |||||
Paper | Condition | Treatment | Method | Studies | Finding |
---|---|---|---|---|---|
Shaddish, Matt, Navarro & Phillips (2000) |
Various |
Various |
Meta-Analysis |
90 |
|
Van Ingen, Freiheit & Vye (2009) |
Anxiety Disorders |
CBT |
Review & Meta-Analysis |
11 |
d = 1.35 (d = 1.14 at follow up) |
Stewart & Chambless (2009) |
Anxiety Disorders |
CBT |
Review & Meta-Analysis |
56 |
Panic (0.83 - 1.23) |
Cahill, Barkham & Stiles (2010) |
Various |
Various |
Review & Meta-Analysis |
31 |
d = 1.29 |
Hunsley, Elliott & Therrien (2014) |
Mood & Anxiety Disorders |
Various |
Narrative Review |
||
Wakefield, Kellett, Simmonds-Buckley, Stockton, Bradbury & Delgadillo (2020) |
Anxiety & Depression |
IAPT |
Meta-Analysis |
47 |
Depression (d = 0.87) |
Considerable growth of PBE in the last decade (and ESTs) 📈.
Previous reviews vary in focus/setting.
Benchmarks that apply to a broad range of services are warranted.
Limited prior attempt to explore why effect-sizes differ.
Aim: Broadly review the literature of PBE studies.
Objectives:
Assess the degree to which treatments are effective.
Provide benchmarks for services to compare to.
Examine sources of heterogeneity using moderator variables.
Extract the effect-size from each study, and pool the results into a single effect.
Throwing everything into a bucket and seeing what comes out.
Problem: Statistical Independence
Various possible solutions
Effectiveness | Psychological | Limiters |
---|---|---|
Practice based evidence | Psycho* OR Therap [PsycInfo] | English Language |
Routine practice | Psycho* [CINAHL and MEDLINE] | Adult Sample |
Benchmarking | ||
Transportability | ||
Transferability | ||
Clinical* representat | ||
External valid* N0 findings | ||
Applicab* N0 findings | ||
Applicab* N0 intervention* | ||
Empiric* support’ N0 treatment | ||
Empiric* support’ N0 intervention | ||
Clinical* Effective*’ | ||
Dissem* N0 treatment* | ||
Dissem* N0 intervention* | ||
Clinical Practice N0 intervention* | ||
Clinical Practice N0 treatment* | ||
Service deliv N0 intervention | ||
Service deliv N0 treatment | ||
Clinical* effective N2 evaluat | ||
Service deliv N0 evaluat | ||
Transporting | ||
Managed care setting | ||
Uncontrolled | ||
Community clinic | ||
Community mental health centre | ||
Clinic setting | ||
Service setting |
Moderator | Levels | Notes |
---|---|---|
Categorical | ||
Setting |
a) Outpatient |
|
Analysis |
a) Included all patients |
|
Severity |
a) Mild services (primary care, physical health, university counselling, voluntary, private, EAP). |
|
Modality |
a) Cognitive-behavioral. |
based on manuscript self-designation (i.e., if the manuscript described treatment as CBT, then that was coded). In the absence of these terms, modality of best-fit was decided using treatment descriptions. |
Continent |
a) North America. |
The UK was separated from Europe because of the high representation of outcomes research coming from the UK |
Intervention Development Stage |
a) Preliminary studies (i.e., novel treatments/conditions). |
|
Experience |
a) Trainees. |
|
Measurement Tool |
Measures that were represented at least ten times in the systematic review | |
Sample Size |
a) Small (N ≤ 25). |
|
Continuous | ||
Age |
Mean average age of sample |
|
Year |
Year of publication |
|
Females |
Rate of females (%) |
Outcome | k | d | 95% CI | p | I2 | Q |
---|---|---|---|---|---|---|
Depression |
140 |
0.96 |
0.90-1.06 |
< 0.001 |
98.4 |
3037.46 |
Anxiety |
84 |
0.8 |
0.73-0.92 |
< 0.001 |
97.52 |
1488.88 |
Other |
184 |
1.01 |
0.93-1.08 |
< 0.001 |
98.92 |
15685.18 |
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals |
Depression Outcomes | |||||
k | d | I2 | 95% CI | Forest Plot | |
---|---|---|---|---|---|
Severity | |||||
Mild | 34 |
1.03 |
100% |
0.85-1.22 |
|
University | 30 |
0.98 |
100% |
0.79-1.16 |
|
Secondary | 57 |
0.98 |
100% |
0.86-1.11 |
|
Residential | 15 |
0.91 |
100% |
0.7-1.12 |
|
Analysis | |||||
Include | 81 |
0.93 |
100% |
0.84-1.03 |
|
Completers | 59 |
1.08 |
100% |
0.94-1.22 |
|
Setting | |||||
Outpatient | 121 |
0.99 |
100% |
0.91-1.08 |
|
Residential | 16 |
0.92 |
100% |
0.72-1.12 |
|
Continent | |||||
North America | 58 |
1 |
100% |
0.88-1.11 |
|
UK | 44 |
1.1 |
100% |
0.94-1.26 |
|
Mainland Europe | 29 |
0.95 |
100% |
0.77-1.12 |
|
Australasia | 4 |
0.67 |
100% |
0.33-1.01 |
|
Asia | 5 |
0.59 |
96% |
0.37-0.8 |
|
Therapy Modality | |||||
Psychodynamic | 24 |
1.03 |
100% |
0.86-1.2 |
|
Counselling | 6 |
0.89 |
100% |
0.69-1.1 |
|
Cognitive-Behavioural | 90 |
1 |
100% |
0.89-1.11 |
|
Other | 20 |
0.96 |
100% |
0.75-1.17 |
|
Tretament Stage | |||||
Routine Evaluations | 118 |
1 |
100% |
0.91-1.09 |
|
Preliminary Studies | 22 |
0.95 |
96% |
0.78-1.12 |
|
Experience | |||||
Qualified | 121 |
1.01 |
100% |
0.92-1.1 |
|
Trainees | 19 |
0.9 |
100% |
0.74-1.06 |
|
Measure | |||||
BDI | 34 |
1.02 |
100% |
0.86-1.18 |
|
PHQ 9 | 30 |
1.01 |
100% |
0.81-1.22 |
|
Sample Size | |||||
Large | 74 |
1.02 |
100% |
0.91-1.13 |
|
Small | 33 |
0.85 |
95% |
0.7-0.99 |
|
Publication Year | |||||
124 |
-0.001 |
||||
Sample Age | |||||
124 |
-0.004 |
||||
% Female | |||||
124 |
0.13 |
||||
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals Summary: d = 0.96, k = 124, Tau2 = 0.17[SE = 0.02], I2 = 99.99%, R2 = 19.28% |
Anxiety Outcomes | |||||
k | Cohen's d | I2 | 95% CI | Forest Plot | |
---|---|---|---|---|---|
Severity | |||||
Mild | 22 | 0.99 | 100% | 0.79-1.2 | |
Secondary | 24 | 0.63 | 100% | 0.5-0.76 | |
Residential | 8 | 0.59 | 100% | 0.29-0.9 | |
University | 29 | 1.01 | 100% | 0.83-1.2 | |
Analysis | |||||
Include | 58 | 0.81 | 100% | 0.69-0.93 | |
Completers | 26 | 0.96 | 100% | 0.77-1.14 | |
Setting | |||||
Outpatient | 75 | 0.89 | 100% | 0.78-0.99 | |
Residential | 9 | 0.58 | 100% | 0.31-0.85 | |
Continent | |||||
North America | 32 | 0.91 | 100% | 0.72-1.1 | |
UK | 25 | 0.89 | 100% | 0.7-1.09 | |
Mainland Europe | 20 | 0.79 | 100% | 0.65-0.93 | |
Australasia | 4 | 0.61 | 100% | 0.21-1.01 | |
Asia | 3 | 0.59 | 40% | 0.49-0.68 | |
Therapy Modality | |||||
Psychodynamic | 12 | 0.90 | 100% | 0.75-1.04 | |
Counselling | 2 | 0.43 | 96% | 0.38-0.49 | |
Cognitive-Behavioural | 62 | 0.87 | 100% | 0.74-1 | |
Other | 8 | 0.75 | 100% | 0.53-0.97 | |
Tretament Stage | |||||
Routine Evaluations | 74 | 0.85 | 100% | 0.74-0.96 | |
Preliminary Studies | 10 | 0.87 | 99% | 0.61-1.14 | |
Experience | |||||
Qualified | 66 | 0.78 | 100% | 0.68-0.88 | |
Trainees | 18 | 1.12 | 100% | 0.86-1.39 | |
Measure | |||||
BAI | 19 | 0.71 | 100% | 0.54-0.88 | |
GAD 7 | 19 | 0.96 | 100% | 0.78-1.15 | |
Sample Size | |||||
Large | 45 | 0.84 | 100% | 0.72-0.95 | |
Medium | 13 | 0.93 | 99% | 0.57-1.3 | |
Small | 26 | 0.84 | 97% | 0.66-1.03 | |
Publication Year | |||||
78 | 0.01 | - | NA | ||
Sample Age | |||||
78 | -0.01 | - | NA | ||
% Female | |||||
78 | -0.22 | - | NA | ||
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals Summary: d = 0.8, k = 78, Tau2 = 0.13[SE = 0.02], I2 = 99.95%, R2 = 40.55% |
Other Outcomes | |||||
k | Cohen's d | I2 | 95% CI | Forest Plot | |
---|---|---|---|---|---|
Severity | |||||
Mild | 61 | 1.08 | 100% | 0.95-1.21 | |
Secondary | 62 | 0.98 | 100% | 0.84-1.12 | |
Residential | 27 | 1.09 | 100% | 0.91-1.26 | |
University | 28 | 0.82 | 100% | 0.7-0.95 | |
Analysis | |||||
Include | 95 | 0.98 | 100% | 0.87-1.09 | |
Completers | 89 | 1.08 | 100% | 0.97-1.18 | |
Setting | |||||
Outpatient | 153 | 1.00 | 100% | 0.92-1.08 | |
Residential | 28 | 1.08 | 100% | 0.91-1.25 | |
Continent | |||||
UK | 68 | 1.02 | 100% | 0.92-1.13 | |
North America | 60 | 1.07 | 100% | 0.9-1.25 | |
Mainland Europe | 47 | 1.00 | 100% | 0.88-1.12 | |
Australasia | 4 | 0.81 | 99% | 0.72-0.9 | |
Asia | 5 | 0.90 | 99% | 0.61-1.2 | |
Therapy Modality | |||||
Cognitive-Behavioural | 83 | 1.18 | 100% | 1.05-1.32 | |
Psychodynamic | 36 | 0.93 | 100% | 0.79-1.07 | |
Counselling | 19 | 0.90 | 100% | 0.75-1.06 | |
Other | 46 | 0.87 | 100% | 0.76-0.98 | |
Tretament Stage | |||||
Preliminary Studies | 24 | 1.06 | 100% | 0.82-1.29 | |
Routine Evaluations | 160 | 1.02 | 100% | 0.94-1.1 | |
Experience | |||||
Qualified | 158 | 1.07 | 100% | 0.99-1.16 | |
Trainees | 26 | 0.77 | 100% | 0.65-0.89 | |
Measure | |||||
BSI-GSI | 26 | 0.87 | 100% | 0.73-1 | |
CORE-OM | 35 | 1.04 | 100% | 0.9-1.18 | |
OQ-45 | 13 | 0.57 | 100% | 0.41-0.74 | |
SCL (Global) | 22 | 1.05 | 100% | 0.87-1.23 | |
PCL | 12 | 1.29 | 100% | 0.97-1.61 | |
Sample Size | |||||
Large | 110 | 1.01 | 100% | 0.92-1.1 | |
Medium | 38 | 1.11 | 99% | 0.92-1.3 | |
Small | 36 | 0.99 | 97% | 0.81-1.18 | |
Publication Year | |||||
153 | 0.00 | - | NA | ||
Sample Age | |||||
153 | 0.00 | - | NA | ||
% Female | |||||
153 | -0.14 | - | NA | ||
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals Summary: d = 1.01, k = 153, Tau2 = 0.24[SE = 0.03], I2 = 100%, R2 = 21.44% |
Multi-Meta Regression | ||||
Depression | Anxiety | Other | Notes | |
---|---|---|---|---|
Continent | ✅ |
✅ |
❌ |
Depression: UK samples had larger effect sizes compared to samples from Asia. |
Severity | ❌ |
✅ |
❌ |
Anxiety: Mild samples had larger effect sizes than moderate or severe samples. |
Modality | ❌ |
✅ |
✅ |
Anxiety: CBT outperformed counselling interventions. |
Treatment Stage | ❌ |
❌ |
❌ |
|
Analysis | ✅ |
❌ |
❌ |
Depression: completer samples outperformed ITT. |
Experience | ✅ |
❌ |
❌ |
Depression: qualified staff outperformed trainees. |
Sample Size | ❌ |
❌ |
❌ |
|
Publication Year | ❌ |
❌ |
❌ |
|
Sample Age | ❌ |
❌ |
❌ |
|
% Female | ❌ |
❌ |
❌ |
Benchmarks | |||
Cohen's d | 95% CI | Forest Plot | |
---|---|---|---|
Anxiety - Outpatient Services | |||
Top 25% | 1.56 |
1.38-1.73 |
|
Average | 0.84 |
0.78-0.89 |
|
Bottom 25% | 0.37 |
0.33-0.42 |
|
Anxiety - Inpatient Services | |||
Top 25% | 1.07 |
1.04-1.09 |
|
Average | 0.67 |
0.42-0.92 |
|
Bottom 25% | 0.13 |
0.03-0.29 |
|
Anxiety - University Outpatient Clinics | |||
Top 25% | 1.8 |
1.57-2.02 |
|
Average | 1.8 |
1.57-2.02 |
|
Bottom 25% | 0.51 |
0.44-0.57 |
|
Depression - Outpatient Services | |||
Top 25% | 1.68 |
1.53-1.83 |
|
Average | 0.94 |
0.9-0.97 |
|
Bottom 25% | 0.46 |
0.41-0.52 |
|
Depression - Inpatient Services | |||
Top 25% | 1.34 |
1.16-1.52 |
|
Average | 0.98 |
0.81-1.15 |
|
Bottom 25% | 0.38 |
0.26-0.5 |
|
Depression - University Outpatient Clinics | |||
Top 25% | 1.77 |
1.5-2.03 |
|
Average | 0.91 |
0.87-0.95 |
|
Bottom 25% | 0.4 |
0.27-0.54 |
|
Other - Outpatient Services | |||
Top 25% | 1.7 |
1.54-1.86 |
|
Average | 0.92 |
0.89-0.96 |
|
Bottom 25% | 0.49 |
0.43-0.54 |
|
Other - Inpatient Services | |||
Top 25% | 1.67 |
1.37-1.97 |
|
Average | 1.04 |
0.96-1.11 |
|
Bottom 25% | 0.58 |
0.46-0.69 |
|
Other - University Counselling Centers | |||
Top 25% | 1.47 |
1.24-1.69 |
|
Average | 0.94 |
0.84-1.03 |
|
Bottom 25% | 0.64 |
0.61-0.67 |
|
Other - University Outpatient Clinics | |||
Top 25% | 1.14 |
1.1-1.18 |
|
Average | 0.86 |
0.77-0.94 |
|
Bottom 25% | 0.41 |
0.23-0.59 |
Treatments are highly effective in routine practice.
Nevertheless, effects vary considerably across services.
Performance benchmarks may help routine services through evaluation and practice development initiatives.
Next step: Do treatment effects last?
Allows services to generate an effect-size and compare it to benchmarks from the paper.
Effectiveness of Routine Psychological Interventions