The Effectiveness of Psychological Interventions in Routine Practice

A research seminar for:

The University of Sheffield Psychology

routine-therapy-outcomes.netlify.app

Dr. Chris Gaskell

Senior Clinical Psychologist

Neuropsychology

North Staffordshire Combined Healthcare NHS Trust

Aims For This Talk

  • Overview of Practice Based Evidence.

  • Rationale for the Current Study.

  • Findings & Limitations.

  • Recent Developments.

Background

What Have we Learnt from Psychotherapy Research RCTs?

  • Psychotherapy works! .

  • Different therapies fare about equal (i.e., Dodo Bird Effect 🐦).

  • Some therapists produce greater outcomes (Super Shrinks? 🦸).

  • Providing feedback on progress leads to greater outcomes 🆙🍄.

  • Much improvement is actually achieved in the early sessions.

The Problems with RCTs?

Advantages of RCTs

  • Reduction of bias

  • High internal validity

  • Reproducibility

  • Objective and reliable

However:

  • High cost and resource-intensive
  • Ethical issues
  • Limited external validity

But do Finding Hold True in (Routine) Practice?

Many reasons to expect that that the effects of psychotherapy delivered in routine care settings may differ from RCTS:

  • Geographical effects.

  • Provision.

  • Empirically Supported Treatments.

  • Integrity.

So what do we do… ?

Practice-Based Evidence

Hour Glass Model

Salkovskis, P. M. (1995). Demonstrating specific effects in cognitive and behavioural therapy, in M. Aveline & D. Shapiro (Eds.), Research foundations for psychotherapy practice (pp. 191–228). Chichester, UK: Wiley. Taken from BABCP: https://babcp.com/Therapists/A-Cognitive-Behavioural-Therapists-Guide-to-Evidence

Past Reviews of Practice Based Research

Table 1: Findings from Past Effectiveness Reviews.
Past Effectiveness Reviews
Paper Condition Treatment Method Studies Finding

Shaddish, Matt, Navarro & Phillips (2000)

Various

Various

Meta-Analysis

90

Van Ingen, Freiheit & Vye (2009)

Anxiety Disorders

CBT

Review & Meta-Analysis

11

d = 1.35 (d = 1.14 at follow up)

Stewart & Chambless (2009)

Anxiety Disorders

CBT

Review & Meta-Analysis

56

Panic (0.83 - 1.23)
SAD (0.73 - 1.04)
PTSD (1.62 - 2.59)
GAD (0.89 - 0.92)
OCD (0.89 - 1.32)

Cahill, Barkham & Stiles (2010)

Various

Various

Review & Meta-Analysis

31

d = 1.29

Hunsley, Elliott & Therrien (2014)

Mood & Anxiety Disorders

Various

Narrative Review

Wakefield, Kellett, Simmonds-Buckley, Stockton, Bradbury & Delgadillo (2020)

Anxiety & Depression

IAPT

Meta-Analysis

47

Depression (d = 0.87)
Anxiety (d = 0.88)
Functioning (d = 0.55)

Rationale

  • Considerable growth of PBE in the last decade (and ESTs) 📈.

  • Previous reviews vary in focus/setting.

  • Benchmarks that apply to a broad range of services are warranted.

  • Limited prior attempt to explore why effect-sizes differ.

Aim: Broadly review the literature of PBE studies.

Objectives:

  1. Assess the degree to which treatments are effective.

  2. Provide benchmarks for services to compare to.

  3. Examine sources of heterogeneity using moderator variables.

Method

What is a Meta-Analysis?

  • Extract the effect-size from each study, and pool the results into a single effect.

  • Throwing everything into a bucket and seeing what comes out.

  • Problem: Statistical Independence

  • Various possible solutions

    • Multiple meta-analyses!

Search Criteria

Table 2: Search criteria used in the systematic review.
Effectiveness Psychological Limiters
Practice based evidence Psycho* OR Therap [PsycInfo] English Language
Routine practice Psycho* [CINAHL and MEDLINE] Adult Sample
Benchmarking
Transportability
Transferability
Clinical* representat
External valid* N0 findings
Applicab* N0 findings
Applicab* N0 intervention*
Empiric* support’ N0 treatment
Empiric* support’ N0 intervention
Clinical* Effective*’
Dissem* N0 treatment*
Dissem* N0 intervention*
Clinical Practice N0 intervention*
Clinical Practice N0 treatment*
Service deliv N0 intervention
Service deliv N0 treatment
Clinical* effective N2 evaluat
Service deliv N0 evaluat
Transporting
Managed care setting
Uncontrolled
Community clinic
Community mental health centre
Clinic setting
Service setting

Moderators

Table 3: Moderators used in the systematic review.
Moderator Levels Notes
Categorical

Setting

a) Outpatient
b) Inpatient
c) Mixed

Analysis

a) Included all patients
b) Only completers

Severity

a) Mild services (primary care, physical health, university counselling, voluntary, private, EAP).
b) Moderate services (secondary care, CMHTs, specialist psychotherapy centers, managed care settings, or intensive outpatient programmes).
c) Severe services (inpatient samples).
d) University clinics (outpatient and training clinics).

Modality

a) Cognitive-behavioral.
b) Psychodynamic.
c) Counselling (e.g., person-centred, undefined).
d) Other.

based on manuscript self-designation (i.e., if the manuscript described treatment as CBT, then that was coded). In the absence of these terms, modality of best-fit was decided using treatment descriptions.

Continent

a) North America.
b) United Kingdom (UK).
c) Mainland Europe.
d) Australasia.
e) Asia

The UK was separated from Europe because of the high representation of outcomes research coming from the UK

Intervention Development Stage

a) Preliminary studies (i.e., novel treatments/conditions).
b) Routine evaluations.

Experience

a) Trainees.
b) Qualified professionals.

Measurement Tool

Measures that were represented at least ten times in the systematic review

Sample Size

a) Small (N ≤ 25).
b) Medium (N = 25–50).
c) large (N = 50+)

Continuous

Age

Mean average age of sample

Year

Year of publication

Females

Rate of females (%)

Findings

PRISMA

Prisma flow diagram of studies throughout the review

Figure 1: Prisma flow diagram of studies throughout the review

Rates of Effectiveness

Table 4: Sub-group (categorical) moderator analyses for depression outcomes.
Outcome k d 95% CI p I2 Q

Depression

140

0.96

0.90-1.06

< 0.001

98.4

3037.46

Anxiety

84

0.8

0.73-0.92

< 0.001

97.52

1488.88

Other

184

1.01

0.93-1.08

< 0.001

98.92

15685.18

k = number of studies, d = Cohen's d effect-size, CI = confidence intervals

Figure 2: Comparisons to Past Effectiveness Reviews.

Depression

Table 5: Sub-group (categorical) moderator analyses for depression outcomes.
Depression Outcomes
k d I2 95% CI Forest Plot
Severity
Mild

34

1.03

100%

0.85-1.22

0.961.220.85
University

30

0.98

100%

0.79-1.16

0.961.160.79
Secondary

57

0.98

100%

0.86-1.11

0.961.110.86
Residential

15

0.91

100%

0.7-1.12

0.961.120.70
Analysis
Include

81

0.93

100%

0.84-1.03

0.961.030.84
Completers

59

1.08

100%

0.94-1.22

0.961.220.94
Setting
Outpatient

121

0.99

100%

0.91-1.08

0.961.080.91
Residential

16

0.92

100%

0.72-1.12

0.961.120.72
Continent
North America

58

1

100%

0.88-1.11

0.961.110.88
UK

44

1.1

100%

0.94-1.26

0.961.260.94
Mainland Europe

29

0.95

100%

0.77-1.12

0.961.120.77
Australasia

4

0.67

100%

0.33-1.01

0.961.010.33
Asia

5

0.59

96%

0.37-0.8

0.960.800.37
Therapy Modality
Psychodynamic

24

1.03

100%

0.86-1.2

0.961.200.86
Counselling

6

0.89

100%

0.69-1.1

0.961.100.69
Cognitive-Behavioural

90

1

100%

0.89-1.11

0.961.110.89
Other

20

0.96

100%

0.75-1.17

0.961.170.75
Tretament Stage
Routine Evaluations

118

1

100%

0.91-1.09

0.961.090.91
Preliminary Studies

22

0.95

96%

0.78-1.12

0.961.120.78
Experience
Qualified

121

1.01

100%

0.92-1.1

0.961.100.92
Trainees

19

0.9

100%

0.74-1.06

0.961.060.74
Measure
BDI

34

1.02

100%

0.86-1.18

0.961.180.86
PHQ 9

30

1.01

100%

0.81-1.22

0.961.220.81
Sample Size
Large

74

1.02

100%

0.91-1.13

0.961.130.91
Small

33

0.85

95%

0.7-0.99

0.960.990.70
Publication Year

124

-0.001

 
Sample Age

124

-0.004

 
% Female

124

0.13

 
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals
Summary: d = 0.96, k = 124, Tau2 = 0.17[SE = 0.02], I2 = 99.99%, R2 = 19.28%

Figure 3: Sub-group (categorical) moderator analyses for depression outcomes.

Anxiety

Table 6: Sub-group (categorical) moderator analyses for anxiety outcomes.
Anxiety Outcomes
k Cohen's d I2 95% CI Forest Plot
Severity
Mild 22 0.99 100% 0.79-1.2 0.801.200.79
Secondary 24 0.63 100% 0.5-0.76 0.800.760.50
Residential 8 0.59 100% 0.29-0.9 0.800.900.29
University 29 1.01 100% 0.83-1.2 0.801.200.83
Analysis
Include 58 0.81 100% 0.69-0.93 0.800.930.69
Completers 26 0.96 100% 0.77-1.14 0.801.140.77
Setting
Outpatient 75 0.89 100% 0.78-0.99 0.800.990.78
Residential 9 0.58 100% 0.31-0.85 0.800.850.31
Continent
North America 32 0.91 100% 0.72-1.1 0.801.100.72
UK 25 0.89 100% 0.7-1.09 0.801.090.70
Mainland Europe 20 0.79 100% 0.65-0.93 0.800.930.65
Australasia 4 0.61 100% 0.21-1.01 0.801.010.21
Asia 3 0.59 40% 0.49-0.68 0.800.680.49
Therapy Modality
Psychodynamic 12 0.90 100% 0.75-1.04 0.801.040.75
Counselling 2 0.43 96% 0.38-0.49 0.800.490.38
Cognitive-Behavioural 62 0.87 100% 0.74-1 0.801.000.74
Other 8 0.75 100% 0.53-0.97 0.800.970.53
Tretament Stage
Routine Evaluations 74 0.85 100% 0.74-0.96 0.800.960.74
Preliminary Studies 10 0.87 99% 0.61-1.14 0.801.140.61
Experience
Qualified 66 0.78 100% 0.68-0.88 0.800.880.68
Trainees 18 1.12 100% 0.86-1.39 0.801.390.86
Measure
BAI 19 0.71 100% 0.54-0.88 0.800.880.54
GAD 7 19 0.96 100% 0.78-1.15 0.801.150.78
Sample Size
Large 45 0.84 100% 0.72-0.95 0.800.950.72
Medium 13 0.93 99% 0.57-1.3 0.801.300.57
Small 26 0.84 97% 0.66-1.03 0.801.030.66
Publication Year
78 0.01 - NA  
Sample Age
78 -0.01 - NA  
% Female
78 -0.22 - NA  
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals
Summary: d = 0.8, k = 78, Tau2 = 0.13[SE = 0.02], I2 = 99.95%, R2 = 40.55%

Figure 4: Sub-group (categorical) moderator analyses for anxiety outcomes.

Other

Table 7: Sub-group (categorical) moderator analyses for other outcomes.
Other Outcomes
k Cohen's d I2 95% CI Forest Plot
Severity
Mild 61 1.08 100% 0.95-1.21 1.011.210.95
Secondary 62 0.98 100% 0.84-1.12 1.011.120.84
Residential 27 1.09 100% 0.91-1.26 1.011.260.91
University 28 0.82 100% 0.7-0.95 1.010.950.70
Analysis
Include 95 0.98 100% 0.87-1.09 1.011.090.87
Completers 89 1.08 100% 0.97-1.18 1.011.180.97
Setting
Outpatient 153 1.00 100% 0.92-1.08 1.011.080.92
Residential 28 1.08 100% 0.91-1.25 1.011.250.91
Continent
UK 68 1.02 100% 0.92-1.13 1.011.130.92
North America 60 1.07 100% 0.9-1.25 1.011.250.90
Mainland Europe 47 1.00 100% 0.88-1.12 1.011.120.88
Australasia 4 0.81 99% 0.72-0.9 1.010.900.72
Asia 5 0.90 99% 0.61-1.2 1.011.200.61
Therapy Modality
Cognitive-Behavioural 83 1.18 100% 1.05-1.32 1.011.321.05
Psychodynamic 36 0.93 100% 0.79-1.07 1.011.070.79
Counselling 19 0.90 100% 0.75-1.06 1.011.060.75
Other 46 0.87 100% 0.76-0.98 1.010.980.76
Tretament Stage
Preliminary Studies 24 1.06 100% 0.82-1.29 1.011.290.82
Routine Evaluations 160 1.02 100% 0.94-1.1 1.011.100.94
Experience
Qualified 158 1.07 100% 0.99-1.16 1.011.160.99
Trainees 26 0.77 100% 0.65-0.89 1.010.890.65
Measure
BSI-GSI 26 0.87 100% 0.73-1 1.011.000.73
CORE-OM 35 1.04 100% 0.9-1.18 1.011.180.90
OQ-45 13 0.57 100% 0.41-0.74 1.010.740.41
SCL (Global) 22 1.05 100% 0.87-1.23 1.011.230.87
PCL 12 1.29 100% 0.97-1.61 1.011.610.97
Sample Size
Large 110 1.01 100% 0.92-1.1 1.011.100.92
Medium 38 1.11 99% 0.92-1.3 1.011.300.92
Small 36 0.99 97% 0.81-1.18 1.011.180.81
Publication Year
153 0.00 - NA  
Sample Age
153 0.00 - NA  
% Female
153 -0.14 - NA  
k = number of studies, d = Cohen's d effect-size, CI = confidence intervals
Summary: d = 1.01, k = 153, Tau2 = 0.24[SE = 0.03], I2 = 100%, R2 = 21.44%

Figure 5: Sub-group (categorical) moderator analyses for other outcomes.

Multiple Meta Regression

Table 8: Multiple meta-regression of moderators included in the review.
Multi-Meta Regression
Depression Anxiety Other Notes
Continent

Depression: UK samples had larger effect sizes compared to samples from Asia.
Anxiety: UK samples had larger effect sizes compared to samples from mainland Europe.

Severity

Anxiety: Mild samples had larger effect sizes than moderate or severe samples.

Modality

Anxiety: CBT outperformed counselling interventions.
Other: CBT outperformed unspecified and psychodynamic interventions.

Treatment Stage

Analysis

Depression: completer samples outperformed ITT.

Experience

Depression: qualified staff outperformed trainees.

Sample Size

Publication Year

Sample Age

% Female

Benchmarks

Table 9: Benchmarks for routine services based on individual study sample quartiles.
Benchmarks
Cohen's d 95% CI Forest Plot
Anxiety - Outpatient Services
Top 25%

1.56

1.38-1.73

1.001.731.38
Average

0.84

0.78-0.89

1.000.890.78
Bottom 25%

0.37

0.33-0.42

1.000.420.33
Anxiety - Inpatient Services
Top 25%

1.07

1.04-1.09

1.001.091.04
Average

0.67

0.42-0.92

1.000.920.42
Bottom 25%

0.13

0.03-0.29

1.000.290.03
Anxiety - University Outpatient Clinics
Top 25%

1.8

1.57-2.02

1.002.021.57
Average

1.8

1.57-2.02

1.002.021.57
Bottom 25%

0.51

0.44-0.57

1.000.570.44
Depression - Outpatient Services
Top 25%

1.68

1.53-1.83

1.001.831.53
Average

0.94

0.9-0.97

1.000.970.90
Bottom 25%

0.46

0.41-0.52

1.000.520.41
Depression - Inpatient Services
Top 25%

1.34

1.16-1.52

1.001.521.16
Average

0.98

0.81-1.15

1.001.150.81
Bottom 25%

0.38

0.26-0.5

1.000.500.26
Depression - University Outpatient Clinics
Top 25%

1.77

1.5-2.03

1.002.031.50
Average

0.91

0.87-0.95

1.000.950.87
Bottom 25%

0.4

0.27-0.54

1.000.540.27
Other - Outpatient Services
Top 25%

1.7

1.54-1.86

1.001.861.54
Average

0.92

0.89-0.96

1.000.960.89
Bottom 25%

0.49

0.43-0.54

1.000.540.43
Other - Inpatient Services
Top 25%

1.67

1.37-1.97

1.001.971.37
Average

1.04

0.96-1.11

1.001.110.96
Bottom 25%

0.58

0.46-0.69

1.000.690.46
Other - University Counselling Centers
Top 25%

1.47

1.24-1.69

1.001.691.24
Average

0.94

0.84-1.03

1.001.030.84
Bottom 25%

0.64

0.61-0.67

1.000.670.61
Other - University Outpatient Clinics
Top 25%

1.14

1.1-1.18

1.001.181.10
Average

0.86

0.77-0.94

1.000.940.77
Bottom 25%

0.41

0.23-0.59

1.000.590.23

What it means

What it Means?

  • Broadest meta-analytic study of routine therapy outcomes (N = 233,140, k = 223)
  • Comparable (large) rates of effectiveness to other reviews of practice based evidence.
  • All continents demonstrated positive change (d = 0.59–1.10) supporting the universality hypothesis (i.e., that psychotherapy is assumed to work across cultures; Flückiger et al., 2018).
  • Some interesting findings from moderators (however there are power issues).

Making Sense of the Moderators

  • Continental Differences? UK/US appeared to outperform some regions.
    • Potentially influenced by differences in models of training, service structures, therapy provision and emphasis on evidence-based practice?
    • Note. Some continents had very few studies.
  • So is Severity not Associated with Effect-Size?
    • Inpatient anxiety samples fared less well.
    • Baseline severity not important for depression?
    • Note. Was our variable an Imprecise proxy?
  • Long live the Dodo Bird?
    • CBT outperformed other treatments for the other outcomes category. Potentially due to influence on specific conditions (e.g., PTSD, OCD)?
    • Absence of evidence for CBT being superior for anxiety or depression category outcomes.
  • Maybe there is something to say for Clinician Experience?
    • Qualified clinicians out performed trainees for depression and other category outcomes.
    • Trainees fared slightly better for anxiety.
      • Potentially less likely to drift from EBP?

Limitations

Limitations and Opportunities

  • Reliance on Observational Evidence.
  • Outcome Domains & Statistical Dependency
  • Did Treatments Intended = Treatment Received.
  • Only Reflects Changes During Treatment Phase.
  • Exclusively Self-Report Data.
  • Nevertheless, valuable benchmarks.
  • Robust variance and/or IPDMA.
  • Re-analysis Focusing upon Fidelity Checks.
  • Re-analysis Focusing upon Follow Up Evidence.
  • Reliance upon Clinician Report as Moderator.

Conclusions

Conclusion

  • Treatments are highly effective in routine practice.

  • Nevertheless, effects vary considerably across services.

  • Performance benchmarks may help routine services through evaluation and practice development initiatives.

  • Next step: Do treatment effects last?

Developments

Publication

Gaskell, C., Simmonds-Buckley, M., Kellett, S., Stockton, C., Somerville, E,. Rogerson E., & Delgadillo, J. (2023). The effectiveness of psychological interventions delivered in routine practice: Systematic review and meta-analysis. Administration and Policy in Mental Health and Mental Health Services Research. 50, 43–57. https://doi.org/10.1007/s10488-022-01225-y

Shiny App for plotting benchmarks

Web App

Allows services to generate an effect-size and compare it to benchmarks from the paper.

Shiny App for plotting benchmarks.

https://chris-gaskell.shinyapps.io/effectiveness-meta-shiny

Thanks for Listening!